Moho Animation by Lost Marble
Moho is our most highly-recommend 2D rig + vector animation software. We absolutely love using Moho, and just look at some of the beautiful, and entirely new, results you can get with it. Everything I see coming out of Moho is getting better in each post they make.
Rebelle by Escape Motions
Rebelle is the most capable and powerful tradigital painting software out there. Just look at some of the amazing work that has been painting using it. The proof is in the pudding!
Clip Studio Paint
Clip Studio Paint is an incredibly one-stop powerhouse — great for digital drawing, painting, comics (with page and paneling capabilities!), AND animation. Wow, what can’t you do with this thing.